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New perspective on the natural course of chronic HBV infection
Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 129-134 doi: 10.1007/s11684-014-0339-x
Chronic hepatitis B virus (HBV) infection is a significant threat to public health and an enormouspre-core mutant becomes predominant in the viral population following elimination of the wild-type virusin duck hepatitis B virus-chronically infected animals.The coupled events in which first there is viral clearance that clears wild-type virus and then thereis the reinfection of wild-type virus cleared livers with mutant virus are highly relevant to understanding
Keywords: hepatitis B virus chronic HBV infection natural course hepatitis B seroconversion
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 399-411 doi: 10.1007/s11684-010-0170-y
Keywords: hepatocellular carcinoma hepatitis B virus X protein β -catenin cell adhesion E-cadherin transcriptional
Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 217-226 doi: 10.1007/s11684-014-0326-2
Keywords: hepatocellular carcinoma (HCC) interaction miRNA-122-binding site IL-1A rs3783553 hepatitis B virus (HBV) mutations
Eliminating mother-to-child transmission of HBV: progress and challenges in China
Wenzhan Jing, Jue Liu, Min Liu
Frontiers of Medicine 2020, Volume 14, Issue 1, Pages 21-29 doi: 10.1007/s11684-020-0744-2
Keywords: hepatitis B virus mother-to-child transmission progress challenge
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 502-508 doi: 10.1007/s11684-017-0590-z
Although the efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitisB, long-term therapy has been recommended due to the high frequency of off-therapy viral DNA reboundIn this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the lifeIn contrast to hepatitis B surface antigen (HBsAg) that can originate from either the cccDNA or the integratedB, to distinguish the “functional cure” characterized as serum HBsAg loss with or without
Keywords: chronic hepatitis B serum HBV RNA nucleos(t)ide analogs virological response para-functional cure
Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China
Rui Yu,Rong Fan,Jinlin Hou
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 135-144 doi: 10.1007/s11684-014-0331-5
Chronic hepatitis B is a major health problem in China.The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infectionThe most prevalent hepatitis B virus strains in China are genotypes B and C, whereas those in westernChronic hepatitis B poses a heavy burden to the society in China.
Keywords: chronic hepatitis B epidemiology prevention treatment
Current hepatitis B treatment guidelines and future research directions
Jonathan Skupsky,Ke-Qin Hu
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 145-157 doi: 10.1007/s11684-014-0335-1
Hepatitis B virus (HBV) infection causes a tremendous clinical burden across the world with more thanhalf a million people dying annually from HBV related disease.Significant advances have been made in HBV treatment in the past decade and several guidelines have beenAlthough these recommendations have been valuable to help optimize HBV treatment, there is discordancein treatment criteria and many patients infected with HBV may fall outside of these recommendations.
Keywords: chronic hepatitis B HBV treatment guidelines APASL guidelines EASL guidelines AASLD guidelines
MicroRNAs and hepatitis viruses
Gang LI MD , Xiaojia XIONG MM ,
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 265-270 doi: 10.1007/s11684-009-0055-0
Keywords: microRNA hepatitis B virus hepatitis C virus
Current advances in the elimination of hepatitis B in China by 2030
Shuye Zhang, Fusheng Wang, Zheng Zhang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 490-501 doi: 10.1007/s11684-017-0598-4
With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leadingAvailable anti-HBV therapy is efficacious in suppressing HBV replication; however, it fails to completelycure patients with chronic hepatitis B and even requires lifelong treatment.virus are common in China and cause severe liver diseases, which should be recognized early and treatedWork is still needed to eliminate hepatitis B in China by 2030.
Keywords: HBV CHB biomarker functional cure coinfection
Current recommendations of managing HBV infection in preconception or pregnancy
James S. Park,Calvin Pan
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 158-165 doi: 10.1007/s11684-014-0340-4
Hepatitis B remains a leading cause of cirrhosis, hepatocellular carcinoma and liver transplantationManagement of chronic hepatitis B during pregnancy is challenging.Transmission of hepatitis B to infants still occurs perinatally although immunoprophylaxis is widelyavailable for infants born to mothers with chronic hepatitis B infection.In this article, we will review the features of hepatitis B infection before, during and after the pregnancy
Keywords: antiviral therapy Caesarean section cirrhosis hepatitis B immunoprophylaxis mother-to-child transmission
Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,
Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 419-429 doi: 10.1007/s11684-010-0160-0
Keywords: hepatitis B virus hepatocellular carcinoma mutation genotype haplotype
Shasha Zhu, Huimin Zhang, Li Bai
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 249-261 doi: 10.1007/s11684-018-0622-3
Keywords: natural killer T cells hepatitis B virus and hepatitis C virus infection autoimmune liver diseases alcoholic
Construction and expression of hepatitis B virus vector encoding TC-tagged core protein
Yuanyuan LIN MD, Xiaoming CHENG MS, Yuhu SONG MD, Peiyuan LI MD, Ying CHANG MM, Jinjian YAO MD, Jusheng LIN MD, PhD, Li ZHOU PhD, Leiming XU PhD,
Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 396-402 doi: 10.1007/s11684-009-0056-z
Keywords: hepatitis B virus vector tetracysteine tag core protein
Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell
Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,
Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 106-111 doi: 10.1007/s11684-010-0004-y
Keywords: hepatitis B virus X gene glomerular mesangial cell line extracellular regulated protein kinases tumor
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 90-95 doi: 10.1007/s11684-010-0021-x
Keywords: cyclooxygenase-2 gene single nucleotide polymorphisms susceptibility primary hepatocellular carcinoma hepatitisB virus infection
Title Author Date Type Operation
New perspective on the natural course of chronic HBV infection
Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan
Journal Article
Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
Journal Article
Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitisB virus mutations with hepatocellular carcinoma risk
Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen
Journal Article
Eliminating mother-to-child transmission of HBV: progress and challenges in China
Wenzhan Jing, Jue Liu, Min Liu
Journal Article
Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Journal Article
Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China
Rui Yu,Rong Fan,Jinlin Hou
Journal Article
Current hepatitis B treatment guidelines and future research directions
Jonathan Skupsky,Ke-Qin Hu
Journal Article
Current advances in the elimination of hepatitis B in China by 2030
Shuye Zhang, Fusheng Wang, Zheng Zhang
Journal Article
Current recommendations of managing HBV infection in preconception or pregnancy
James S. Park,Calvin Pan
Journal Article
Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular
Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,
Journal Article
Construction and expression of hepatitis B virus vector encoding TC-tagged core protein
Yuanyuan LIN MD, Xiaoming CHENG MS, Yuhu SONG MD, Peiyuan LI MD, Ying CHANG MM, Jinjian YAO MD, Jusheng LIN MD, PhD, Li ZHOU PhD, Leiming XU PhD,
Journal Article
Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell
Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,
Journal Article